CURRICULUM VITAE FOR


JAN AKERVALL, MD., PH.D.


Revised March, 2004

Education
 
High School education:
1976-1979
St Lars High School, Linkoping, Sweden; Natural science program
Undergraduate education:
1981-1982
Chalmers Institution of Technology, Gothenburg, Sweden: Theoretical Physics
 
1980-1981
Linkoping University, Sweden; Mathematics
 
1991-1992
Internship (AT), Angelholms sjukhus, Sweden
Medical school:
1983-1989
Medical School, Lund University, Sweden
PhD degree
1993-1998
Lund University, dept of ORL/H&N Surgery, Lund, Sweden;
(Thesis: Prognostic markers in squamous cell carcinoma of the head and neck, mentors: Prof Johan Wennerberg, dept of ORL, and Associate Prof Fredrik Mertens, dept of Clinical Genetics). Courses in Epidemiology (1993), Research Methodology (1994), Molecular Biology for oncologists (1994), DNA-based Clinical Diagnistics (1995), Information sources (1995), Genetics and Cancer (1996), Methodology of publication (1996 & 1997), Survival analysis (1996), Medical Ethics (1997), Problem based education/tutor course (1998).
 
1993-1998
ENT training, clinical, including courses in Leadership, Otoneurology, Middle ear surgery, Sinus surgery, Laryngology, Radiobiology, Radiation Oncology
 
1994-1999
Pain treatment in cancer patients (Swedish Cancer Society)
Academic Appointments:
1986-1987
Lecturer in Pathology, Lund University, Sweden
 

1994-1996

Lecturer in Otolaryngogly/Head & Neck Surgery, Lund University, Sweden
 

1996 - 1997

Member of the board of The Jubilee Institution, University Hospital, Lund, Sweden
 

1996-1997

Member of the Educational Board at Medical Faculty, Lund University. Introduced mandatory basic science education for doctoral students.
 

1998-1999

Head of education program for ENT specialists in southern
Sweden
 
2000-2001
Head and neck tumour and reconstructive surgery fellow, Dept of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Postdoc in tumour Biology, Dept of Otolaryngology, Head and Neck Surgery, University Hospital, Ann Arbor, Michigan, USA
 
2003
Associate Professor, Dept of Otolaryngogly/Head & Neck Surgery, Lund University, Sweden


 
2003
Head of education program for ENT specialists in southern
Sweden
Certification and Licensure:
 
 
1990
MD, Lund University, Sweden
 

1998

Board Certification, ENT, Head and Neck Surgery, Sweden
 

2000

Temporary Academic License, Michigan
 

2002

Permanent MD license, Michigan (Permanent I.D. no. 4301075498
     
Honors and Awards    
 
1996
Best poster award, Swedish Society for Otorhinolaryngology
 

1998

Tegger Foundation, Malmoe, Sweden
 

1998

Teknibro Foundation, Lund University, Sweden
 

2004

Buyers award nomination, 6th International Conference on Head and Neck Cancer, Washington, August 2004
 

2004

Michigan Technological Tri-corridor Fund (2.6 Mill dollars for SensiGen corp.)
Commercial Scientific Achievements    
 
2001
Incorporator, SensiGen Corporation.
 
2002
US Patent 6,341,608 B1 (January 29, 2002). Novel surgical method of resecting tumors.
Sscholarships    
 
1994
GAE Nilssons Foundation
Maggie Stephens Foundation
 

1995

The Swedish Society of Medicine
The Lund Society of Medicine
Swedish Cancer Foundation
 

1996

Swedish Cancer Foundation
Maggie Stephen's Foundation
The Royal Fysiographic Society
 

1997

GAE Nilssons Foundation
Maggie Stephens Foundation
 

1998

Maggie Stephen's Foundation
 

1999

Maggie Stephen's Foundation
 

2000

Swedish Cancer Society, postdoc scholarship Swedish Society for Medical Research, postdoc scholarship
 

2002

GAE Nilssons Cancer Society
 

2003

GAE Nilssons Cancer Society, Maggie Stephen's Foundation
 
         
Memberships and Offices in Profesional Societies

 

The Swedish Society of Medicine
The Lund Society of Medicine
Swedish Medical Association
The southern swedish oncologic society
Swedish Society for Otorhinolaryngology, Head and Neck Surgery
Scandinavian Society for Head and Neck Oncology
American Association for Cancer Research (AACR)
American Academy of Otolaryngology – Head and Neck Surgery (AAO-HNS).
Michigan Oto-Laryngological Society

 

Extramural Invited Presentations

”Cyclin D1 in squamous cell carcinoma of the head and neck”. Invited lecture at Danish Society for Head and Neck Oncology, Copenhagen, Denmark, February 1, 1997, and at 4th International Conference on Head and Neck Cancer Biology,
Mc Lean, USA, August 1998

“Predictive markers in squamous cell carcinoma of the head and neck”. Invited lecture and panel discussion for EUFOS 2000 (European Otolaryngology Academy meeting), Berlin, Germany, May 2001

“Genetic markers to individualize treatment of squamous cell carcinoma of the head and neck.” Invited lecture 8th World Congress on Advances in Oncology, Crete, Greece, October 2003.

“Limiting cancer spread – prevention of implantation metastases”. Invited lecture 2nd European Conference on Head and Neck Surgery, Lille, France, October 2003.

“Gene profiling in squamous cell carcinoma of the head and neck”. Invited lecture and panellist at EUFOS 2004, Rhodes, Greece, September, 2004.

“Bone anchored Mucosal flap for reconstruction of anterior floor of mouth and gingival.” Michigan Otolaryngological Society, Bay Harbour, Michigan, USA, July 2005.

 

Invited Charimarn at Scientific Meetings

4th International Conference on Head and Neck Cancer Biology, Mc Lean, USA, August 1998

3rd European Workshop on Head and Neck Cancer Biology, Oslo, Norway, April 1998.

The International Symposium on Metastasis in Head Neck Cancer, Marburg, Germany, January 25-27, 2001

The Fourth European Workshop on Head and Neck Biology, Amsterdam, Netherlands, October 3-6, 2001

VII Symposium on research in Head and Neck Cancer, Dusseldorf, Germany, September 5-8, 2003

8th World Congress on Advances in Oncology, Crete, Greece, October 16-18, 2003

Research Collaborators

Prof. F Mertens, MD, PhD, Dept of Clinical Genetics, University Hospital, Lund, Sweden, since 1993. Cytogenetic studies
Assoc prof. U Zatterstrom, MD, PhD, Dept of Otolaryngology, Head and Neck Surgery, Rikshospitalet, Oslo, Norway, since 1993. Malignancy grading studies

Assoc prof. A Borg, PhD, Dept of Oncology, University Hospital, Lund, Sweden, since 1995 Differential PCR, FISH
Prof. J Isola, MD, PhD, Dept of Medical Technology, Tampere University, Finland, since 1996. FISH

Prof. F Balm, MD, PhD and R Michalides, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands, since 1996. Cyclin D1immunohistochemistry

Prof. T Carey, PhD, University of Michigan, Ann Arbor, USA, since 1998. Cell culture, western blotting, chemosensitivity studies. Head of current lab (postdoc)

Prof. A El-Naggar, MD, PhD, Dept of Pathology, MD Anderson Cancer Institute, Houston, Texas, USA, since 1998. Multi-center cyclin D1 study

Assoc prof. C Bradford, MD, Dept of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, USA, since 2000. Chemosensitivity studies, microvascular reconstructive surgery

Prof. B Teh, MD, PhD, Van Andel Research Institute, Grand Rapids, Michigan, USA, since 2000. Spectro karyotyping, cDNA and CGH micro-arrays

Prof. R Greinman, MD, PhD, Dept of Otolaryngology, Head and Neck Surgery, Abo University, Finland, since 2000. Cell culture and cytogenetic.

Priv doc, Dr Dr H Bier, MD, PhD, Dept of Otolaryngology, Head and Neck Surgery, Dusseldorf University, Germany, since 2000. Cell culture and cytogenetic
.
Priv doc, Dr Dr U Bockmuhl, MD, PhD, Dept of Otolaryngology, Head and Neck Surgery, Humbolt University, Berlin, Germany, since 2001. CGH vs real-time PCR study.
Prof. Mans Magnusson, Dept of ENT, Lund, Sweden. International Head and Neck Cancer Biology studies.
Dr. Peter Chen, M.D., Beaumont Hospital, Royal Oak, Michigan. Genetic markers for head and neck cancer
Dr. Neal Goldstein, M.D., Beaumont Hospital, Royal Oak, Michigan. Genetic markers for head and neck cancer

 

Research Supervision

Supervised 2 nurses and 7 medical students in clinical studies (Lund, Sweden, and Ann Arbor, Michigan, USA), 1997-2003

Co-supervisor (bitr handledare) 2 doctoral students (ENT and Oncology) 2003

Supervising 2 residents at William Beaumont Hospital in Head and Neck Cancer studies.


Clinical Supervision

Surgical supervision of residents in University of Michigan, Department of Otolaryngology, 2000-2002, and at Lund University, Department of Otolaryngology 1998-1999, and 2002-
   
Newspaper Articles and other media cover of Jan Akervall

Medical thesis about prognostic markers in head and neck cancer awarded by Tegger’s foundation. Skanska Dagbladet (Swedish newspaper) 1998

New surgical procedure for reconstructions of anterior floor of mouth defects. Dagens Medicin (Daily Medicine) 2003.

Re-organisation based on personal responsibility cuts waiting lists. Lakartidningen (National journal for Swedish physicians) 2004

New model for health care organization cuts waiting lists. Dagens Medicin (Daily Medicine) 2004

Personal responsibility cuts waiting lists – new organizational model. Kvalitetsmagasinet (Swedish national magazine for public and private organizations) 2004.

3 years waiting list for thyroidectomies became 3 weeks by new organizational method. Dagens Eko (National public Radio, Sweden) 2004.

Dramatically shortened waitng lists for elective surgery by new method. TV4 news (National TV news, Sweden) 2004.
8 He cut the waiting lists by a smarter organization. Fokus (Swedish Newsweek) 2005.

Bibliography
Completed publications in Scientific Journals
 Peer reviewed Publications J Rollof, J Akervall and J Rydberg. Are tumour necrosis factor (TNF) or Cortisol of value for the diagnosis of acute septicemia? Scand J Infect Dis 22: 507-508, 1990.

J Akervall, Y Jin, J Wennerberg, U K Zatterstrom, E Kjellen, R Willen, F Mertens, N Mandahl, S Heim and F Mitelman. Chromosomalabnormalities involving 11q13 are associated with poor prognosis in squamous cell carcinoma of the head and neck. Cancer 76:853-859, 1995

Y Jin, F Mertens, C Jin, J Akervall, J Wennerberg, L Gorunova, N Mandahl, S Heim and F Mitelman. Nonrandome chromosome abnormalities in short-term cultured primary squamous cell carcinoma of the head and neck. Cancer Res 55:3204-3210, 1995.

J Akervall, R Michalides, H Mineta, A Balm, A Borg, M Dictor, Y Jin, B Loftus, F Mertens, P Wahlberg, and J Wennerberg. Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer 79:380-389, 1997.

C Jin, Y Jin, J Wennerberg, J Akervall, B Grenthe, N Mandahl, S Heim, F Mitelman, and F Mertens. Clonal chromsome aberrations accumulate with age in upper aerodigestive tract. Mutation Res 374:63-72, 1997.

C Jin, Y Jin, J Wennerberg, J Akervall, M Dictor, N Mandahl, S Heim, F Mitelman, and F Mertens. Cytogenetic analysis of inverted nasal papillomas and demonstration of genetic convergence during in vitro passaging. Int J Cancer 70:668-673, 1997.

J Akervall, Y Jin, B Baldetorp and J Wennerberg. Complex karyotypes in flowcytometrically DNA-diploid squamous cell carcinomas of the head and neck. Br J Cancer 77:1082-1088, 1998.

C Jin, Y Jin, M Hoglund, J Wennerberg, J Akervall, R Willen, M Dictor, N Mandahl, F Mitelman and F Mertens. Cytogenetic and molecular genetic demonstration of polyclonality in an acinic cell carcinoma. Br J Cancer 78:292-295, 1998.

H Mineta, A Borg, M Dictor, P Wahlberg, J Akervall, and J Wennerberg. p53 mutation, But not p53 expression, correlates with survival in head and neck carcinoma. Br J Cancer 77:1082-1088, 1998.

Y Jin, M Hoglund, C Jin, C Martins, J Wennerberg, J Akervall, N Mandahl, F Mitelman and F Mertens. FISH characterization of head and neck carcinomas reveals that amplification of band 11q13 is associated with distal deletion of 11q. Genes, Chromosomes & Cancer 22:213-320, 1998.

G Thorneman, and J Akervall. Pain treatment after tonsillectomy: Advantages for regularly given analgesics compared with given on demand. Acta Otolaryngologica, Stockholm 120; 986-989; 2000

J Akervall, R Michalides, M Dictor, E Brun, F Balm, and J
Wennerberg. Cyclin D1 overexpression versus response to induction chemotherapy in squamous cell carcinoma of the head and neck. Acta Oncologica 40;505-12; 2001.

J Akervall, A Borg, M Dictor, Y Jin, F Mertens, and J Wennerberg. Chromosomal translocations involving 11q13 contribute to cyclin D1 overexpression in squamous cell carcinoma of the head and neck. Int J Oncol 2002;20; 45-52.

C Jin, Y Jin, J Wennerberg, J Akervall, M Dictor, and F Mertens. Karyotypic heterogeneity and clonal evolution in squamous cell carcinomas of the head and neck. Cancer Genet Cytogenet 132; 85-96; 2002.

J Akervall, U Bockmuhl, P Pedersen, T Carey, and D Kurnit.The gene ratios c-myc/p16 and cyclin D1/p16 correlates with poor prognosis in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2003;9;1750-1755.

J Akervall, D Kurnit, M Adams, B Zhu, S Fisher, C Bradford, and T Carey. Overexpression of Cyclin D1 Correlates with Sensitivity to Cisplatin in Squamous Cell Carcinoma Cell Lines of the Head and Neck. Acta Otolaryngol 124:851-857, 2004

E Nimeus, K Rennstam, J Wennerberg, J Akervall, M Ferno. Amplification of Cyclin D1, ploidy status and s-phase fraction correlates with tumor localisation in squamous cell carcinoma of the head and neck. Oral Oncol. 2004 Jul;40(6):624-9.

J Akervall, X Guo, M Qian, J Schoumans, A Cole, B Leeser, J Resau, C Bradford, T Carey, J Wennerberg, H Anderson, J Tennvall, B T. Teh Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients. Clin Cancer Res. 2004 Dec 15;10(24):8204-13.

M Dictor, M Ehinger, F Mertens, J Akervall and J Wennerberg. Abnormal cell regulation in malignancy. Am J Pathol 112 (suppl. 1):40-52, 1999.

J Akervall. Genetic profiling in squamous cell carcinoma of the head and neck. Cancer Met Rev 24:87-94, 2005

J Akervall. Genomic screening of head and neck cancer. European Archives of Oto-Rino-Laryngology (in press).

E. Henriksson, J. Akervall et al. p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck. Acta Oncologica (in press).


Book chapters J Akervall, F Mertens and J Wennerberg. Chromosomal abnormalities in squamous cell carcinoma of the head and neck. In Kitamura K., Steel KP (eds.): ”Genetics in ORL. Adv Otorhinolaryngology”, Basel, Karger, 2000;56:261-7
Medical thesis

J Akervall. Prognostic factors in squamous cell carcinoma of the head and neck. With emphasis on 11q13 rearrangements and cyclin D1 overexpression. (1998)

   
Extensive proceedings J Akervall, R Michalides, H Mineta, A Balm, A Borg, M Dictor, Y Jin, B Loftus, F Mertens, P Wahlberg, and J Wennerberg. Amplification and overexpression of cyclin D1, and chromosomal abnormalities in squamous cell carcinoma of the head and neck. In Head and Neck Cancer Advances in Basic Research, pp 213-218, Elsevier, Amsterdam-Lausanne-New York-Oxford-Shannon-Tokyo, 1996.

J Wennerberg, B Baldetorp and J Akervall. The efficacy of DNA flow cytometry in squamous cell carcinoma of the head and neck. In Head and Neck Cancer Advances in Basic Research, pp 599-605, Elsevier,Amsterdam-Lausanne-New York-Oxford-Shannon-Tokyo, 1996.

J Akervall, David Kurnit, Meredith Adams, Bob Zhu, Susan Fischer, Carol Bradford, and Thomas Carey. Deregulation of cyclin D1 and p16 and their relation to Cisplatin sensitivity in squamous cell carcinoma cell lines of the head and neck. In Metastases in Head and Neck Cancer, pp 223-226, Tectum Verlag, Marburg, Germany 2001.

   
Articles submitted for publication J Akervall, J Prager, D Kurnit, T Ogawa, T Carey, and C Bradford. Characterization of homzygous deletions affecting tumour suppressor genes p16INK4A and p14ARF in 25 squamous cell carcinoma of the head and neck cell lines.

J Akervall. Bone anchored mucosal flap for reconstruction of anterior floor of mouth after tumor resection including partial mandibulectomy – pilot study of 8 patients.

   
Abstract presentations since 2000 (during 1994-2000: another 26 abstract presentations in different international meetings)

 

 

Predictive markers in squamous cell carcinoma of the head and neck. Presented at EUFOS 2000, Berlin 13-18 Maj, 2000-05-22 J Akervall (invited speaker)


Etablering och karaktarisering av sex humana skivepitelcancercellinjer fran huvud- och halsregionen. Presented at the Swedish National Medical Conference, Stockholm 2000-11-29—12-01 E.Lundahl, B. Baldetorp, F. Mertens, P. Wahlberg, J. Wennerberg and J. Akervall

Amplifiering av cyclin D1 genen CCND1 i skivepitelcancer i huvud- och halsregionen. Presented at the Swedish National Medical Conference, Stockholm 2000-11-29—12-01 E. Nimmeus, K. Annertz, M. Ferno, J. Akervall, and J. Wennerberg.

Overexpression of Cyclin D1 Correlates with Sensitivity to Cisplatin in Squamous Cell Carcinoma Cell Lines of the Head and Neck. J Akervall, D Kurnit, M Adams, B Zhu, S Fisher, C Bradford, and T Carey. Presented at The International Symposium on Metastasis in Head Neck Cancer, Marburg, Germany, January 25-27, 2001

Overexpression of Cyclin D1 Correlates with Sensitivity to Cisplatin in Squamous Cell Carcinoma Cell Lines of the Head and Neck. J Akervall, D Kurnit, M Adams, B Zhu, S Fisher, C Bradford, and T Carey. Presented at The American Association for Cancer Research 92nd Annual Meeting, New Orleans, Lousiana, USA, March 24-28, 2001

Overexpression of Cyclin D1 Correlates with Sensitivity to Cisplatin in Squamous Cell Carcinoma Cell Lines of the Head and Neck. J Akervall, D Kurnit, M Adams, B Zhu, S Fisher, C Bradford, and T Carey. Presented at University of Michigan Translational Cancer Conference, USA, April, 2001

Overexpression of Cyclin D1 Correlates with Sensitivity to Cisplatin in Squamous Cell Carcinoma Cell Lines of the Head and Neck. The Fourth European Workshop on Head and Neck Biology, Amsterdam, Netherlands, October 3-6, 2001


J Wennerberg, C Jin, Y Jin, J Akervall, M Dictor, and F Mertens. Klonal evolution och cytogenetisk heterogenitet i skivepitelcancer i huvud- och halsregionen. Presented at the Swedish National Medical Conference, Stockholm , 2001-11-28—30


Amplification of p53 I squamous cell carcinoma cell lines. Presented at The American Association for Cancer Research 93nd Annual Meeting, San Francisco, California, USA, April 6-10, 2002:


Genetic and expression profiles of squamous cancer cell lines of the head and neck correlate with cisplatin sensitivity and resistance. Jan Akervall, Xiang Guo, Miles Qian, Jacqueline Schoumans, Jason Yuhas, Andrew Cole, Brandon Leeser, James Resau, Carol Bradford, Thomas Carey, Harald Anderson, Jan Tennvall, Bin T. Teh Presented at The American Association for Cancer Research 93nd Annual Meeting, Washington, USA, July 10-14, 2003

Presented at Scandinavian Society for Head and Neck Oncology, Trondheim, Norway, May 2-4, 2003, Jan Akervall, Xiang Guo, Miles Qian, Jacqueline Schoumans, Jason Yuhas, Andrew Cole, Brandon Leeser, James Resau, Carol Bradford, Thomas Carey, Harald Anderson, Jan Tennvall, Bin T. Teh Presented at The American Association for Cancer Research 93nd Annual Meeting, Washington, USA, July 10-14, 2003


Presented at ECCO12, Copenhagen, Denmark, September 21-25, 2003, Jan Akervall, Xiang Guo, Miles Qian, Jacqueline Schoumans, Jason Yuhas, Andrew Cole, Brandon Leeser, James Resau, Carol Bradford, Thomas Carey, Harald Anderson, Jan Tennvall, Bin T. Teh Presented at The American Association for Cancer Research 93nd Annual Meeting, Washington, USA, July 10-14, 2003.

Presented at VII Symposium on research in Head and Neck Cancer, Dusseldorf, Germany, September 4-6, 2003. Jan Akervall, Xiang Guo, Miles Qian, Jacqueline Schoumans, Jason Yuhas, Andrew Cole, Brandon Leeser, James Resau, Carol Bradford, Thomas Carey, Harald Anderson, Jan Tennvall, Bin T. Teh Presented at The American Association for Cancer Research 93nd Annual Meeting, Washington, USA, July 10-14, 2003

Akervall, U Bockmuhl, P Pedersen, T Carey, and D Kurnit.The gene ratios c-myc/p16 and cyclin D1/p16 correlates with poor prognosis in squamous cell carcinoma of the head and neck. Presented at Scandinavian Society for Head and Neck Oncology, Trondheim, Norway May 2-4, 2003.


Jan Akervall, Xiang Guo, Miles Qian, Jacqueline Schoumans, Andrew Cole, Brandon Leeser, James Resau, Carol Bradford, Thomas Carey, Harald Anderson, Jan Tennvall, Bin T. Teh Genetic and expression profiles correlate with cisplatin sensitivity and resistance in cell lines and patients with squamous cell carcinoma of the head and neck. Presented at 6th Inrenational Conference on Head and Neck Cancer, Washington, August 2004:


Jan Akervall, Xiang Guo, Miles Qian, Jacqueline Schoumans, Andrew Cole, Brandon Leeser, James Resau, Carol Bradford, Thomas Carey, Harald Anderson, Jan Tennvall, Bin T. Teh Genetic and expression profiles correlate with cisplatin sensitivity and resistance in cell lines and patients with squamous cell carcinoma of the head and neck.Presented at Scandinavian Society for Head and Neck Oncology, Oulo, Finland, April 2004:


J Akervall. Bone anchored mucosal flap for reconstruction of anterior floor of mouth after tumor resection including partial mandibulectomy – pilot study of 6 patients. Presented at Scandinavian Society for Head and Neck Oncology, Oulo, Finland, April 2004.

Jan Akervall, Eugene Rontal, Michael Rontal, Jens Alm, Paulina Gyllerup, Ylva Gardinger, Johan Wennerberg, Sarah Scollon, Pete Haak, Brian Haab, Ed Dere, Kyle Furge, and Bin Teh. Expression profiles in pre-treatment biopsies from SCC of the head and neck correlate with outcome of radiotherapy. AHNS, Boca Raton, Florida, USA May 15-16, 2005

J Akervall. Bone anchored mucosal flap for reconstruction of anterior floor of mouth after tumor resection including partial mandibulectomy – pilot study of 8 patients. Michigan Otolaryngological Society, Harbor Springs, Michigan, July 2005.